NADK Gene Summary [Human]
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NADK |
| Official Name | NAD kinase [Source:HGNC Symbol;Acc:HGNC:29831] |
| Ensembl ID | ENSG00000008130 |
| Bio databases IDs | |
| Aliases | NAD kinase |
| Synonyms | 4432404C02RIK, dJ283E3.1, FLJ13052, NADK1, NAD kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NADK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-NAD kinase C-terminal domain
- ATP-NAD kinase N-terminal domain
- enzyme
- protein binding
- NAD kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- metastatic colorectal cancer
- organismal death
role in cell
- expression in
- migration
- invasion by
- phosphorylation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NADK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP metabolic process
- NAD metabolic process
- phosphorylation
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- NADP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- NAD+ kinase activity
- ATP binding
- protein binding
- metal ion binding