ID1
ID1 Gene Summary
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ID1 |
| Official Name | inhibitor of DNA binding 1, HLH protein [Source:HGNC Symbol;Acc:HGNC:5360] |
| Ensembl ID | ENSG00000125968 |
| Bio databases IDs | |
| Aliases | inhibitor of DNA binding 1, HLH protein, DNA-binding protein inhibitor ID-1, inhibitor of differentiation 1 |
| Synonyms | bHLHb24,D2Wsu140e,ID,ID125A,Id1b,Idb1,inhibitor of DNA binding 1,inhibitor of DNA binding 1, HLH protein |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- nuclear localization sequence
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- helix-loop-helix domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the ID1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- USP7
- TCF3
- BHLH
- MYC
- B4GALT7
- NR4A1
- USP10
- GSN
- TCF12
- PIAS1
disease
- prostatic adenocarcinoma
- leukemia
- diabetes mellitus
- neoplasia
- epithelial cancer
- cancer
- adenoma formation
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
regulated by
- bucladesine
- ethanol
- beta-estradiol
- T lymphocytes
- SMAD4
- testosterone
- BMP2
- BMPR1A
- TLR3
- BMP4
regulates
- MYC
- SNAI1
- MMP9
- CASP3
- PARP
- TNF
- ALDH1A1
- MMP2
- TP53
- AKT
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- growth
- cell viability
- cell death
- formation
- invasion
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ID1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- angiogenesis
- cell differentiation
- transforming growth factor beta receptor signaling pathway
- blood vessel morphogenesis
- negative regulation of transcription by transcription factor localization
- negative regulation of sequence-specific DNA binding transcription factor activity
- blood vessel endothelial cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein dimerization activity