PDCD11 Gene Summary [Human]
PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDCD11 |
| Official Name | programmed cell death 11 [Source:HGNC Symbol;Acc:HGNC:13408] |
| Ensembl ID | ENSG00000148843 |
| Bio databases IDs | |
| Aliases | programmed cell death 11 |
| Synonyms | 1110021I22Rik, ALG-4, KIAA0185, mKIAA0185, NFBP, Pdcd7, programmed cell death 11, RRP5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein S1-like RNA-binding domain
- S1_like
- ribosomal protein S1
- S1 RNA binding domain
- NF-kappaB binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- insomnia
role in cell
- proliferation
- activation in
- G2/M phase
- degradation in
- binding in
- pluripotency
- ubiquitination in
- processing in
- CSN5i-3 sensitivity
- cellular reprogramming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- granules
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- small-subunit processome
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- RNA binding
- protein binding