DYRK4 Gene Summary [Human]
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | DYRK4 |
| Official Name | dual specificity tyrosine phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:HGNC:3095] |
| Ensembl ID | ENSG00000010219 |
| Bio databases IDs | |
| Aliases | dual specificity tyrosine phosphorylation regulated kinase 4 |
| Synonyms | AW049118, dual-specificity tyrosine phosphorylation regulated kinase 4, DYRK4A, DYRK4B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYRK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the DYRK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYRK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein binding
- metal ion binding
- protein serine/threonine kinase activity