STARD3NL Gene Summary [Human]
This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | STARD3NL |
| Official Name | STARD3 N-terminal like [Source:HGNC Symbol;Acc:HGNC:19169] |
| Ensembl ID | ENSG00000010270 |
| Bio databases IDs | |
| Aliases | STARD3 N-terminal like |
| Synonyms | 0610035N01Rik, 6530409L22RIK, LOC102557384, MENTHO, STARD3 N-terminal like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STARD3NL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholesterol binding
- Cholesterol-capturing domain
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- lysosome
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- early endosomes
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STARD3NL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- endosome
- intracellular membrane-bounded organelle
- organelle membrane contact site
- membrane
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- cholesterol binding