DKK3 Gene Summary [Human]
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DKK3 |
| Official Name | dickkopf WNT signaling pathway inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:2893] |
| Ensembl ID | ENSG00000050165 |
| Bio databases IDs | |
| Aliases | dickkopf WNT signaling pathway inhibitor 3, regulated in glioma, cardiomyocyte regeneration-related lncRNA |
| Synonyms | CRRL, DICKKOPF HOMOLOG 3, dickkopf WNT signaling pathway inhibitor 3, mDkk-3, p29, REIC, RIG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DKK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- protein binding
- cytokine
- first cysteine-rich (Cys-1) domain of Dickkopf proteins
Pathways
Biological processes and signaling networks where the DKK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- prostate cancer
- diabetic nephropathy
- endometriosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- systemic lupus erythematosus
- COVID-19
- hyperactive behavior
- breast carcinoma
- Huntington disease
role in cell
- cell death
- expression in
- apoptosis
- number
- proliferation
- quantity
- invasiveness
- growth
- adhesion
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell periphery
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DKK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of transcription, DNA-dependent
- negative regulation of cortisol biosynthetic process
- Wnt receptor signaling pathway
- anatomical structure morphogenesis
- regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of aldosterone biosynthetic process
- adrenal gland development
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor antagonist activity