DHX8 Gene Summary [Human]
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DHX8 |
| Official Name | DEAH-box helicase 8 [Source:HGNC Symbol;Acc:HGNC:2749] |
| Ensembl ID | ENSG00000067596 |
| Bio databases IDs | |
| Aliases | DEAH-box helicase 8 |
| Synonyms | DDX8, DEAH-box helicase 8, Dhr2, HRH1, LRRGT00035, mDEAH6, mKIAA4096, PRP22, PRPF22, Putative RNA helicase homolog, RNA helicase HRH1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Ribosomal protein S1-like RNA-binding domain
- S1_like
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- helicase superfamily c-terminal domain
- GIPC homology 2 (GH2) domain-like family
- enzyme
- protein binding
- RNA dependent ATPase
- identical protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- Helicase associated domain (HA2) Add an annotation
- S1 RNA binding domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- liver cancer
- lung cancer
- Dupuytren contracture
- metabolic syndrome X
- acute myeloid leukemia
role in cell
- expression in
- cell viability
- processing in
- splicing by
- replication in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- cytosol
- spliceosomes
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spliceosomal complex disassembly
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- catalytic step 2 spliceosome
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- cytosol
- intracellular
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- RNA binding
- RNA helicase activity
- RNA-dependent ATPase activity