GTF2F1 Gene Summary [Human]
Enables several functions, including RNA polymerase II general transcription initiation factor activity; phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; response to virus; and transcription initiation from RNA polymerase II promoter. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GTF2F1 |
| Official Name | general transcription factor IIF subunit 1 [Source:HGNC Symbol;Acc:HGNC:4652] |
| Ensembl ID | ENSG00000125651 |
| Bio databases IDs | |
| Aliases | general transcription factor IIF subunit 1 |
| Synonyms | 2810405L04Rik, BTF4, C76800, general transcription factor IIF, polypeptide 1, general transcription factor IIF subunit 1, RAP74, TF2F1, TFIIF, TFIIF alpha, TFIIF α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF2F1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RAP30-binding domain
- globular domain
- protein phosphatase binding
- transcription factor binding
- protein domain specific binding
- chromatin binding
- phosphatase activator
- protein binding
- general RNA polymerase II transcription factor
- Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
Pathways
Biological processes and signaling networks where the GTF2F1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF2F1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- negative regulation of protein binding
- transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- intracellular membrane-bounded organelle
- cell junction
- macromolecular complex
- transcription factor TFIIF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- protein binding
- RNA binding
- protein phosphatase binding
- TFIIF-class transcription factor binding
- general RNA polymerase II transcription factor activity
- phosphatase activator activity
- RNA polymerase II basal transcription factor binding