MAP4K3 Gene Summary [Human]
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAP4K3 |
| Official Name | mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865] |
| Ensembl ID | ENSG00000011566 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase kinase 3 |
| Synonyms | 4833416M01Rik, 4833416M07Rik, 9530052P13Rik, GCKR, GLK, MAPKKKK3, MEKKK 3, mitogen-activated protein kinase kinase kinase kinase 3, RAB8IPL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4K3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- proline rich domain
- SH3-domain binding
- Sh3 domain binding motif
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP4K3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- filopodia
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4K3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- JNK cascade
- response to UV
- protein phosphorylation
- intracellular signal transduction
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- MAP kinase kinase kinase kinase activity