TNFRSF8 Gene Summary [Human]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF8 |
| Official Name | TNF receptor superfamily member 8 [Source:HGNC Symbol;Acc:HGNC:11923] |
| Ensembl ID | ENSG00000120949 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 8 |
| Synonyms | CD30, D1S166E, Ki, Ki-1, TNF receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8, tumour necrosis factor receptor superfamily, member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- extracellular domain
- TRAF binding domain
- protease binding
- cytoplasmic domain
- intracellular domain
- TNFR/NGFR cysteine-rich region
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Sézary syndrome
- mycosis fungoides
- cutaneous T-cell lymphoma
- atopic dermatitis
- diffuse large B-cell lymphoma
- asthma
- recurrent cutaneous T-cell lymphoma
- nodular lymphocyte predominance Hodgkin disease
- cutaneous large cell lymphoma
- CD30 positive anaplastic large cell lymphoma
role in cell
- apoptosis
- growth
- expression in
- proliferation
- cellular infiltration by
- activation in
- production in
- phosphorylation in
- number
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- nucleoplasm
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of TRAIL production
- cellular response to mechanical stimulus
- signal transduction
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- positive regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protease binding