ARNTL2 Gene Summary [Human]
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | ARNTL2 |
| Official Name | aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol;Acc:HGNC:18984] |
| Ensembl ID | ENSG00000029153 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor nuclear translocator like 2, member of PAS superfamily 9 |
| Synonyms | 4632430A05RIK, Arnt4, ARNTL2, basic helix-loop-helix ARNT like 2, bHLHe6, CLIF, LOC102555341, LOC272322, MOP9, PASD9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARNTL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- PAS fold
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- PAS domain
- helix loop helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- non-small cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- expression in
- proliferation
- quantity
- production in
- growth
- cell cycle progression
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARNTL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circadian regulation of gene expression
- entrainment of circadian clock
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of circadian rhythm
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- aryl hydrocarbon receptor complex
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding