ZFYVE16 Gene Summary [Human]
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | ZFYVE16 |
| Official Name | zinc finger FYVE-type containing 16 [Source:HGNC Symbol;Acc:HGNC:20756] |
| Ensembl ID | ENSG00000039319 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 16, endofin, protein phosphatase 1, regulatory subunit 69 |
| Synonyms | B130024H06RIK, B130031L15, mKIAA0305, PPP1R69, RGD1564784, zinc finger, FYVE domain containing 16, zinc finger FYVE-type containing 16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFYVE16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- phosphatidylinositol-3,4,5-triphosphate binding
- smad binding domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- protein binding
- Domain of unknown function (DUF3480)
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endosomal fractions
- intracellular membrane-bounded organelle
- Cytoplasm
- endosomes
- vesicles
- cytosol
- endosomal membrane
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFYVE16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle organization
- signal transduction
- endosomal transport
- regulation of endocytosis
- protein targeting to lysosome
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- metal ion binding
- 1-phosphatidylinositol binding