TOM1 Gene Summary [Human]
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | TOM1 |
| Official Name | target of myb1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11982] |
| Ensembl ID | ENSG00000100284 |
| Bio databases IDs | |
| Aliases | target of myb1 membrane trafficking protein |
| Synonyms | IMD85, target of myb1 membrane trafficking protein, target of myb1 trafficking protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- myosin binding
- clathrin box motif
- VHS, ENTH and ANTH domain superfamily
- clathrin binding
- ubiquitin binding
- protein binding
- GAT domain
- phosphatidylinositol binding
- transporter
- Domain present in VPS-27, Hrs and STAM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- paraproteinemia
- plasma cell myeloma
- Alzheimer disease
- immunodeficiency 85 and autoimmunity
- inflammatory bowel disease
- Rett syndrome
- memory deficits
- ulcerative colitis
role in cell
- phosphorylation in
- molecular cleavage in
- accumulation in
- activation in
- maturation
- transport
- phagocytosis by
- organization
- internalization in
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- secretory granule membrane
- specific granule membrane
- cytosol
- lysosome membrane
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein transport
- endosomal transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- extracellular vesicular exosome
- endosome
- cytoplasm
- membrane
- cytosol
- endosome membrane
- azurophil granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- protein binding
- ubiquitin binding
- polyubiquitin binding
- phosphatidylinositol-5-phosphate binding
- myosin VI binding
- clathrin binding