CKAP2 Gene Summary [Human]
This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | CKAP2 |
| Official Name | cytoskeleton associated protein 2 [Source:HGNC Symbol;Acc:HGNC:1990] |
| Ensembl ID | ENSG00000136108 |
| Bio databases IDs | |
| Aliases | cytoskeleton associated protein 2, tumor-associated microtubule-associated protein |
| Synonyms | AI461656, AW228814, cytoskeleton associated protein 2, LB1, se20-10, TMAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CKAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytoskeleton-associated protein 2 C-terminus
- KEN box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- colorectal cancer
- breast carcinoma
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- rectal adenocarcinoma
- colorectal carcinomagenesis
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- CKAP2
role in cell
- apoptosis
- formation
- blebbing
- blebbing in
- dissociation
- depolymerization
- formation in
- morphology
- cell cycle progression
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- spindle apparatus
- cytoskeleton
- cilia
- Nucleus
- basal bodies
- centrosome
- centriole
- microtubules
- nucleoli
- spindle pole
- polar microtubule
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CKAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis after mitosis
- apoptotic process
- negative regulation of microtubule depolymerization
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule cytoskeleton
- mitotic spindle
- cytoplasm
- spindle pole
- microtubule