WWC3 Gene Summary [Human]
This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | WWC3 |
| Official Name | WWC family member 3 [Source:HGNC Symbol;Acc:HGNC:29237] |
| Ensembl ID | ENSG00000047644 |
| Bio databases IDs | |
| Aliases | WWC family member 3 |
| Synonyms | BM042, RGD1560666, WWC family member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WWC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- kinase binding
- WW
- protein binding activity, bridging
- WW domain
- C2 domain
- Tho complex subunit 7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WWC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hippo signaling cascade
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of hippo signaling cascade
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- hippo signaling cascade
- negative regulation of organ growth
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- signaling adaptor activity
- kinase binding
- binding, bridging