CELF2 Gene Summary [Human]
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CELF2 |
| Official Name | CUGBP Elav-like family member 2 [Source:HGNC Symbol;Acc:HGNC:2550] |
| Ensembl ID | ENSG00000048740 |
| Bio databases IDs | |
| Aliases | CUGBP Elav-like family member 2 |
| Synonyms | B230218O03, B230345P09RIK, BRUNOL3, CUG-BP2, CUGBP Elav-like family member 2, CUGBP, Elav-like family member 2, D230046B21Rik, DEE97, ETR-3, LOC105376406, LOC105376407, mETR-3, NAPOR, NAPOR-1, Napor-2, Napor-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CELF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- side effect
- juvenile dermatomyositis
- acute myeloid leukemia
- open-angle glaucoma
- Alzheimer disease
- idiopathic scoliosis
- prostate cancer
- developmental and epileptic encephalopathy type 97
- Huntington disease
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- invasion by
- G2/M phase
- outgrowth
- quantity
- sphere formation by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Flemming body
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CELF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of heart contraction
- mRNA splice site selection
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- mRNA 3'-UTR binding