KLHDC10 Gene Summary [Human]
Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KLHDC10 |
| Official Name | kelch domain containing 10 [Source:HGNC Symbol;Acc:HGNC:22194] |
| Ensembl ID | ENSG00000128607 |
| Bio databases IDs | |
| Aliases | kelch domain containing 10, scruin like at the midline homolog (Drosophila) |
| Synonyms | 2410127E18Rik, kelch domain containing 10, KIAA0265, LOC100287552, mKIAA0265, PNAS-138, RGD1309792, slim |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHDC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- protein binding activity, bridging
- protein binding
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHDC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- positive regulation of stress-activated MAPK cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Cul2-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding