NOP58 Gene Summary [Human]
The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | NOP58 |
| Official Name | NOP58 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:29926] |
| Ensembl ID | ENSG00000055044 |
| Bio databases IDs | |
| Aliases | NOP58 ribonucleoprotein |
| Synonyms | HSPC120, MSSP, Nap65, Nol5, NOP5, NOP58 ribonucleoprotein, NOP5/NOP58, Nucleolar protein 5, nucleolar protein NOP5/NOP58, SIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOP58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- NOP5NT (NUC127) domain
- binding protein
- snoRNA binding domain, fibrillarin
- snoRNA binding
- transcription factor binding
- enzyme
- protein binding
- NOSIC (NUC001) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- fibrillar center
- pre-ribosome
- cytosol
- nucleoplasm
- nucleoli
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOP58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snoRNA localization
- ribosomal small subunit biogenesis
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- box C/D snoRNP complex
- small-subunit processome
- pre-snoRNP complex
- membrane
- Cajal body
- cytosol
- nucleolus
- small nucleolar ribonucleoprotein complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- snoRNA binding
- protein binding
- TFIID-class transcription factor binding
- ATPase binding