KIFC1 Gene Summary [Human]
Predicted to enable microtubule binding activity and minus-end-directed microtubule motor activity. Involved in mitotic metaphase plate congression and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | KIFC1 |
| Official Name | kinesin family member C1 [Source:HGNC Symbol;Acc:HGNC:6389] |
| Ensembl ID | ENSG00000056678 |
| Bio databases IDs | |
| Aliases | kinesin family member C1 |
| Synonyms | HSET, KIFC5A, kinesin family member C1, KINESIN-RELATED, KNSL2, MHCB, MKLP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIFC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- Autophagy protein 16 (ATG16)
- Ezrin/radixin/moesin, alpha-helical domain
- Myosin and Kinesin motor domain
- enzyme
- protein binding
- Synaptonemal complex central element protein 1
- Kinesin motor, catalytic domain
- microtubule binding
- SynN
- Kinesin motor domain
- Growth-arrest specific micro-tubule binding
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- minus-end-directed kinesin ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- metastasis
- organismal death
- mammary neoplasm
- chromosomal instability
- uterine serous papillary cancer
- colon cancer
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
role in cell
- migration
- number
- apoptosis
- proliferation
- expression in
- morphology
- epithelial-mesenchymal transition
- organization
- survival
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- Nucleus
- centrosome
- endocytotic vesicle
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIFC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic sister chromatid segregation
- microtubule-based movement
- mitotic metaphase plate congression
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- early endosome
- mitotic spindle
- microtubule organizing center
- membrane
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- microtubule binding