GRSF1 Gene Summary [Human]
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRSF1 |
| Official Name | G-rich RNA sequence binding factor 1 [Source:HGNC Symbol;Acc:HGNC:4610] |
| Ensembl ID | ENSG00000132463 |
| Bio databases IDs | |
| Aliases | G-rich RNA sequence binding factor 1 |
| Synonyms | D5Wsu31e, G-RICH RNA binding FACTOR, G-rich RNA sequence binding factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRSF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
role in cell
- expression in
- replication in
- autophagy in
- autophagy
- processing in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein granule
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRSF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- mitochondrial RNA catabolic process
- regulation of RNA splicing
- anterior/posterior pattern specification
- morphogenesis of embryonic epithelium
- mRNA processing
- positive regulation of mitochondrial RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleoplasm
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- G-quadruplex RNA binding