MTFR1 Gene Summary [Human]
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]
Details
| Type | Processed Transcript |
| Official Symbol | MTFR1 |
| Official Name | mitochondrial fission regulator 1 [Source:HGNC Symbol;Acc:HGNC:29510] |
| Ensembl ID | ENSG00000066855 |
| Bio databases IDs | |
| Aliases | mitochondrial fission regulator 1, likely ortholog of chicken chondrocyte protein with a poly proline region |
| Synonyms | 1300002C08Rik, 1700080D04Rik, 2810026O10Rik, 4930579E05Rik, CHPPR, FAM54A2, KIAA0009, mitochondrial fission regulator 1, RGD1304936 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTFR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Mitochondrial fission regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTFR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aerobic respiration
- mitochondrion organization
- mitochondrial fission
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding