TRAM1 Gene Summary [Human]
This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | TRAM1 |
| Official Name | translocation associated membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:20568] |
| Ensembl ID | ENSG00000067167 |
| Bio databases IDs | |
| Aliases | translocation associated membrane protein 1 |
| Synonyms | 1810049E02Rik, LOC100130862, PNAS8, TRAM, TRAMP, translocating chain-associating membrane protein 1, translocation associated membrane protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- TRAM1-like protein
- signaling receptor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Huntington disease
- salivary duct carcinoma
- salivary duct cancer
- mucoepidermoid carcinoma
- lichen planus
- preeclampsia
- acinar-cell carcinoma
regulates
- cytokine
- TICAM1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- cotranslational protein targeting to membrane
- protein insertion into ER membrane
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity