TICAM1 Gene Summary [Human]
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | TICAM1 |
| Official Name | toll like receptor adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:18348] |
| Ensembl ID | ENSG00000127666 |
| Bio databases IDs | |
| Aliases | toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1, TIR domain-containing adaptor-inducing interferon-beta, proline-rich, vinculin and TIR domain-containing protein B |
| Synonyms | AW046014, IIAE6, MyD88-3, PRVTIRB, TIR domain containing adaptor molecule 1, TOLL-LIKE receptor ADAPTOR MOLECULE 1, TRIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TICAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- protein kinase binding
- protein binding activity, bridging
- TBK1-binding domain
- SEFIR domain
- protein binding
- TIR domain
- TRAF6 binding domain
- TRIF N-terminal domain
- receptor interacting protein homotypic interaction motif
- BB loop
- RIP homotypic interaction motif
- Toll IL-1 receptor domain helix B
Pathways
Biological processes and signaling networks where the TICAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- weight loss
- infection
- infection by bacteria
- infection by virus
- susceptibility to herpes simplex encephalitis type 4
- hypersensitivity reaction type I
- airway hyperresponsiveness
- acute lung injury
- bronchoconstriction
role in cell
- proliferation
- cell death
- apoptosis
- production in
- expression in
- killing
- phosphorylation in
- activation in
- cellular infiltration by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- endosomes
- Mitochondria
- lipid droplets
- cytosol
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TICAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- macrophage activation involved in immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- apoptotic signaling pathway
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of macrophage cytokine production
- inflammatory response
- positive regulation of myeloid dendritic cell cytokine production
- positive regulation of interferon-beta production
- response to exogenous dsRNA
- positive regulation of protein ubiquitination
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- B cell proliferation
- regulation of protein complex assembly
- toll-like receptor signaling pathway
- positive regulation of autophagy
- cellular response to lipopolysaccharide
- innate immune response
- positive regulation of gene expression
- positive regulation of natural killer cell activation
- toll-like receptor 3 signaling pathway
- positive regulation of B cell proliferation
- lipopolysaccharide-mediated signaling pathway
- nitric oxide biosynthetic process
- positive regulation of interleukin-6 production
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- mitochondrion
- cytosol
- endosome membrane
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- signaling adaptor activity
- binding, bridging