DHX29 Gene Summary [Human]
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | DHX29 |
| Official Name | DExH-box helicase 29 [Source:HGNC Symbol;Acc:HGNC:15815] |
| Ensembl ID | ENSG00000067248 |
| Bio databases IDs | |
| Aliases | DExH-box helicase 29 |
| Synonyms | 3732415M03, DDX29, Ddxx, DExH-box helicase 29, E130202M19Rik, LOC100362324 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- translation activator
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme
- Helicase conserved C-terminal domain
- AAA domain
- nucleoside-triphosphatase
- Helicase associated domain (HA2) Add an annotation
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- formation of translation preinitiation complex
- ribosome assembly
Cellular Component
Where in the cell the gene product is active
- cytosolic small ribosomal subunit
- eukaryotic 43S preinitiation complex
- intracellular
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- translation initiation factor activity
- ATP binding
- RNA binding
- RNA helicase activity
- cadherin binding
- translation activator activity
- ribosomal small subunit binding
- nucleoside-triphosphatase activity
- helicase activity