TRO Gene Summary [Human]
This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Details
| Type | Protein Coding |
| Official Symbol | TRO |
| Official Name | trophinin [Source:HGNC Symbol;Acc:HGNC:12326] |
| Ensembl ID | ENSG00000067445 |
| Bio databases IDs | |
| Aliases | trophinin |
| Synonyms | MAGE-d3, Maged3l, magphinin, Tnn, Trol, trophinin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mechanosensitive ion channel porin domain
- MAGE homology domain
- nuclear localization sequence
- protein binding
- Keratin type II head
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- homophilic cell adhesion
- embryo implantation
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding