SCT Gene Summary [Human]
This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | SCT |
| Official Name | secretin [Source:HGNC Symbol;Acc:HGNC:10607] |
| Ensembl ID | ENSG00000070031 |
| Bio databases IDs | |
| Aliases | secretin, prepro-secretin |
| Synonyms | Secr, Secretin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptide hormone
- G-protein-coupled receptor binding
- hormone
- protein binding
- digestive hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- diabetes mellitus
- dermatomyositis
- primary biliary cirrhosis
- pancreatitis
- intraductal papillary mucinous neoplasm
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- formation in
- cell death
- calcium response in
- growth
- inhibition in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of appetite
- cellular water homeostasis
- signal transduction
- positive regulation of somatostatin secretion
- positive regulation of pancreatic juice secretion
- positive regulation of cAMP-mediated signaling
- hippocampus development
- brain development
- diet induced thermogenesis
- embryonic digestive tract development
- regulation of synaptic plasticity
- response to nutrient levels
- pancreatic juice secretion
- positive regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- digestive hormone activity
- receptor binding
- hormone activity