SCTR Gene Summary [Human]
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SCTR |
| Official Name | secretin receptor [Source:HGNC Symbol;Acc:HGNC:10608] |
| Ensembl ID | ENSG00000080293 |
| Bio databases IDs | |
| Aliases | secretin receptor |
| Synonyms | 6530402O03Rik, SECR, secretin receptor, SR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCTR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- peptide binding
- N-linked glycosylation site
- transmembrane domain
- secretin receptor
- extracellular loop
- loop domain
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the SCTR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- weight gain
- primary biliary cirrhosis
- polyuria
- polydipsia
- irritable bowel syndrome
- autism
- abdominal pain
- glomerulosclerosis
- pancreatitis
role in cell
- expression in
- proliferation
- growth
- formation in
- binding in
- number
- plasticity
- acidification
- internalization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- basolateral membrane
- endocytotic vesicle
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCTR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of appetite
- G-protein coupled receptor signaling pathway
- cellular water homeostasis
- regulation of synaptic plasticity
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- response to nutrient levels
- diet induced thermogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- secretin receptor activity
- peptide hormone binding