ARHGAP10 Gene Summary [Human]
Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | ARHGAP10 |
| Official Name | Rho GTPase activating protein 10 [Source:HGNC Symbol;Acc:HGNC:26099] |
| Ensembl ID | ENSG00000071205 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 10 |
| Synonyms | A930033B01Rik, FLJ20896, GRAF2, LOC684731, PS-GAP, PSGAP-m, PSGAP-s, Rho GTPase activating protein 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- BAR domain of APPL family
- PH domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the ARHGAP10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- epithelial cancer
- cardiomyopathy
- hepatocellular carcinoma
- liver cancer
- melanoma
- melanoma cancer
- hypertension
- colorectal cancer
- liver cirrhosis
role in cell
- apoptosis
- morphology
- organization
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- signal transduction
- regulation of small GTPase mediated signal transduction
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity