ING3 Gene Summary [Human]
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ING3 |
| Official Name | inhibitor of growth family member 3 [Source:HGNC Symbol;Acc:HGNC:14587] |
| Ensembl ID | ENSG00000071243 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family member 3 |
| Synonyms | 1300013A07Rik, Eaf4, ING2, inhibitor of growth family member 3, inhibitor of growth family, member 3, MEAF4, P47ING3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ING3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- histone lysine acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase
- protein binding activity, bridging
- PHD finger superfamily
- Inhibitor of growth (ING) domain family
- protein binding
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- peripheral T-cell lymphoma
role in cell
- apoptosis
- lipotoxicity in
- G1 phase
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ING3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- Swr1 complex
- nucleosome
- Piccolo NuA4 histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- methylated histone residue binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- H4 histone acetyltransferase activity
- H2A histone acetyltransferase activity
- histone acetyltransferase activity (H4-K12 specific)