SIVA1 Gene Summary [Human]
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Details
| Type | Protein Coding |
| Official Symbol | SIVA1 |
| Official Name | SIVA1 apoptosis inducing factor [Source:HGNC Symbol;Acc:HGNC:17712] |
| Ensembl ID | ENSG00000184990 |
| Bio databases IDs | |
| Aliases | SIVA1 apoptosis inducing factor |
| Synonyms | CD27BP, SIVA, SIVA1 apoptosis inducing factor, SIVA1, apoptosis-inducing factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIVA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD27 receptor binding
- SAH domain
- viral receptor
- tumor necrosis factor receptor binding
- zinc ion binding
- protein binding
- Cd27 binding protein (Siva)
Pathways
Biological processes and signaling networks where the SIVA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Duchenne muscular dystrophy
role in cell
- expression in
- phosphorylation in
- apoptosis
- inhibition in
- cell death
- colony formation
- 5-fluorouracil sensitivity
- activation in
- activation-induced cell death
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nuclear foci
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIVA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- tumor necrosis factor receptor binding
- CD27 receptor binding
- viral receptor activity