SLC6A15 Gene Summary [Human]

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Details

Type
Protein Coding
Official Symbol
SLC6A15
Official Name
solute carrier family 6 member 15 [Source:HGNC Symbol;Acc:HGNC:13621]
Ensembl ID
ENSG00000072041
Bio databases IDs NCBI: 55117 Ensembl: ENSG00000072041
Aliases solute carrier family 6 member 15, homolog of rat orphan transporter v7-3, sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7
Synonyms 6430590A10RIK, AA536730, hv7-3, NTT73, SBAT1, solute carrier family 6 member 15, solute carrier family 6 (neurotransmitter transporter), member 15, V7-3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC6A15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • neutral amino acid:sodium symporter
  • branched-chain amino acid:sodium symporter
  • Sodium:neurotransmitter symporter family
  • protein binding
  • Solute carrier families 5 and 6-like; solute binding domain
  • proline:sodium symporter
  • amino acid transporter
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • alloxan-induced diabetic nephropathy
  • major depression
  • chronic stress disorder
regulates
  • neutral amino acid
  • L-proline
  • amino acids
role in cell
  • activation
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cellular membrane
  • perikaryon
  • axons

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC6A15 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neurotransmitter transport
  • neutral amino acid transport
  • sodium ion transmembrane transport
  • proline transport
  • amino acid transport
  • amino acid transmembrane transport
  • leucine transport

Cellular Component

Where in the cell the gene product is active
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • neurotransmitter transporter activity
  • protein binding
  • neutral amino acid:sodium symporter activity
  • amino acid transmembrane transporter activity
  • proline:sodium symporter activity
  • branched-chain amino acid:sodium symporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.