ZFYVE26 Gene Summary [Human]
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Details
| Type | Retained Intron |
| Official Symbol | ZFYVE26 |
| Official Name | zinc finger FYVE-type containing 26 [Source:HGNC Symbol;Acc:HGNC:20761] |
| Ensembl ID | ENSG00000072121 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 26, spastizin, FYVE-CENT |
| Synonyms | 4930465A13, 9330197E15RIK, A630028O16Rik, FYVE-CENT, Gm893, KIAA0321, mKIAA0321, SPG15, zinc finger, FYVE domain containing 26, zinc finger FYVE-type containing 26 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFYVE26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- protein kinase binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spastic paraplegia
- spastic paraplegia type 15
- luminal A breast carcinoma
- luminal A breast cancer
- astrocytosis
- hereditary spastic paraplegia
- hereditary disorder
- gait disturbance
- kyphosis
- prostate cancer
role in cell
- abnormal morphology
- quantity
- degeneration
- cytokinesis in
- cytokinesis
- outgrowth
- organization
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- lysosome
- centriole
- midbody
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFYVE26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- cytokinesis after mitosis
- regulation of cytokinesis
- double-strand break repair via homologous recombination
Cellular Component
Where in the cell the gene product is active
- centrosome
- early endosome
- late endosome
- midbody
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- metal ion binding
- phosphatidylinositol-3-phosphate binding