Aldh3a2 Gene Summary [Rat]
Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and response to reactive oxygen species. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh3a2 |
| Official Name | aldehyde dehydrogenase 3 family, member A2 [Source:RGD Symbol;Acc:61866] |
| Ensembl ID | ENSRNOG00000002342 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 3 family, member A2 |
| Synonyms | ALD10, aldehyde dehydrogenase 3 family member A2, aldehyde dehydrogenase 3 family, member A2, ALDH10, Aldh4, FALDH, SLS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh3a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- Acyl-CoA reductase (LuxC)
- aldehyde dehydrogenase (NAD)
- long-chain-aldehyde dehydrogenase
- aldehyde dehydrogenase
- long-chain-alcohol oxidase
- phenylacetaldehyde dehydrogenase
- protein homodimerization
- enzyme
- protein binding
- methylmalonic acid semialdehyde dehydrogenase
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh3a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- delayed hypersensitive reaction
- Sjögren-Larsson syndrome
- psoriasis
- aortic valve calcification
- preeclampsia
- oral leukoplakia
- oral lichen planus
regulates
- ceramide
- reactive oxygen species
- d18:1/48:3 omega-O-linoleoyl-ceramide
- long-chain aldehyde
- d18:1/52:2 omega-O-linoleoyl-ceramide
- d18:1/50:2 omega-O-linoleoyl-ceramide
- aldehyde
- geranylgeranial
- formaldehyde
- d18:1/54:2 omega-O-linoleoyl-ceramide
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh3a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular aldehyde metabolic process
- central nervous system development
- epidermis development
- hexadecanal metabolic process
- peripheral nervous system development
- phytol metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisomal membrane
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- protein homodimerization activity
- protein binding
- medium-chain-aldehyde dehydrogenase activity
- long-chain-alcohol oxidase activity
- long-chain-aldehyde dehydrogenase activity