TRHDE Gene Summary [Human]
This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Details
| Type | Processed Transcript |
| Official Symbol | TRHDE |
| Official Name | thyrotropin releasing hormone degrading enzyme [Source:HGNC Symbol;Acc:HGNC:30748] |
| Ensembl ID | ENSG00000072657 |
| Bio databases IDs | |
| Aliases | thyrotropin releasing hormone degrading enzyme, pyroglutamyl-peptidase II, pyroglutamyl aminopeptidase II, TRH-specific aminopeptidase |
| Synonyms | 9330155P21Rik, PAP-II, PGPEP2, Ppii, thyrotropin-releasing hormone degrading enzyme, TRH-degrading ectoenzyme, TRH-degrading enzyme |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRHDE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase M1 N-terminal domain
- Peptidase family M1 domain
- ERAP1-like C-terminal domain
- peptidase
- aminopeptidase
- peptidase GluZincin family
- pyroglutamyl-peptidase II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRHDE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide catabolic process
- signal transduction
- proteolysis
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyroglutamyl-peptidase activity
- zinc ion binding
- metalloaminopeptidase activity
- peptide binding
- aminopeptidase activity