CACNG4 Gene Summary [Human]

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

Details

Type
Protein Coding
Official Symbol
CACNG4
Official Name
calcium voltage-gated channel auxiliary subunit gamma 4 [Source:HGNC Symbol;Acc:HGNC:1408]
Ensembl ID
ENSG00000075461
Bio databases IDs NCBI: 27092 Ensembl: ENSG00000075461
Aliases calcium voltage-gated channel auxiliary subunit gamma 4
Synonyms AI413107, AW491861, CACGN4, calcium channel, voltage-dependent, gamma subunit 4, calcium channel, voltage-dependent, γ subunit 4, calcium voltage-gated channel auxiliary subunit gamma 4, calcium voltage-gated channel auxiliary subunit γ 4, TARP gamma-4, TARP γ-4
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CACNG4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PMP-22/EMP/MP20/Claudin family
  • ionotropic glutamate receptor binding
  • ion channel
  • calcium channel regulator

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • absence seizure
  • SAPHO syndrome
regulated by
  • beta-estradiol
  • HRAS
  • DNMT1
  • 10E,12Z-octadecadienoic acid
  • BB0603
  • MI-2-2
  • TK1
  • THZ531
  • lactic acid
role in cell
  • replication in
  • paired-pulse depression in
  • transmission

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • endocytic vesicle membrane
  • cell surface
  • somatodendritic region
  • cellular membrane
  • synaptic membrane
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CACNG4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium ion transmembrane transport
  • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
  • response to cocaine
  • positive regulation of synaptic transmission, glutamatergic
  • transmission of nerve impulse

Cellular Component

Where in the cell the gene product is active
  • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
  • cell body
  • plasma membrane
  • endocytic vesicle membrane
  • cell surface

Molecular Function

What the gene product does at the molecular level
  • ionotropic glutamate receptor binding
  • calcium channel regulator activity
  • voltage-gated calcium channel activity
  • channel regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.