UBE2T Gene Summary [Human]
The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | UBE2T |
| Official Name | ubiquitin conjugating enzyme E2 T [Source:HGNC Symbol;Acc:HGNC:25009] |
| Ensembl ID | ENSG00000077152 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 T |
| Synonyms | 2700084L22Rik, FANCT, HSPC150, PIG50, RGD1310816, UBCH17, UBIQUITIN-CONJUGATING ENZYME E2 HOMOLOG, ubiquitin-conjugating enzyme E2T |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2T often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- chromatin binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2T gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- Fanconi anemia group T
- gastric adenocarcinoma
- gastric epithelial cancer
- breast cancer
- small cell lung cancer
role in cell
- colony formation
- degradation in
- ubiquitination in
- K48 polyubiquitination in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2T gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein K29-linked ubiquitination
- protein polyubiquitination
- protein K63-linked ubiquitination
- response to DNA damage stimulus
- protein monoubiquitination
- protein K27-linked ubiquitination
- protein K6-linked ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding
- chromatin binding