Ube2t Gene Summary [Mouse]
Predicted to enable chromatin binding activity; ubiquitin conjugating enzyme activity; and ubiquitin protein ligase binding activity. Predicted to be involved in DNA repair and protein ubiquitination. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; limb bud; nasal cavity epithelium; and thymus primordium. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group T. Orthologous to human UBE2T (ubiquitin conjugating enzyme E2 T). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2t |
| Official Name | ubiquitin-conjugating enzyme E2T [Source:MGI Symbol;Acc:MGI:1914446] |
| Ensembl ID | ENSMUSG00000026429 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2T |
| Synonyms | 2700084L22Rik, FANCT, HSPC150, PIG50, RGD1310816, UBCH17, UBIQUITIN-CONJUGATING ENZYME E2 HOMOLOG, ubiquitin-conjugating enzyme E2T |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2t often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- chromatin binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2t gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- Fanconi anemia group T
- gastric adenocarcinoma
- gastric epithelial cancer
- breast cancer
- small cell lung cancer
role in cell
- colony formation
- degradation in
- ubiquitination in
- K48 polyubiquitination in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2t gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein K29-linked ubiquitination
- protein polyubiquitination
- protein K63-linked ubiquitination
- response to DNA damage stimulus
- protein monoubiquitination
- protein K27-linked ubiquitination
- protein K6-linked ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding
- chromatin binding