TBL3 Gene Summary [Human]
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TBL3 |
| Official Name | transducin beta like 3 [Source:HGNC Symbol;Acc:HGNC:11587] |
| Ensembl ID | ENSG00000183751 |
| Bio databases IDs | |
| Aliases | transducin beta like 3 |
| Synonyms | 9430070M15Rik, SAZD, transducin (beta)-like 3, transducin beta like 3, transducin (β)-like 3, transducin β like 3, UTP13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Utp13 specific WD40 associated domain
- WD40 repeats
- peptidase
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- 90S preribosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- U3 snoRNA binding