TRPM3 Gene Summary [Human]
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRPM3 |
| Official Name | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] |
| Ensembl ID | ENSG00000083067 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily M member 3, melastatin 2 |
| Synonyms | 6330504P12RIK, AU018608, CTRCT50, GON-2, LTRPC3, MLSN2, NEDFSS, transient receptor potential cation channel subfamily M member 3, transient receptor potential cation channel, subfamily M, member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRPM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetramerization domain of TRPM
- Ion transport protein
- binding protein
- SLOG in TRPM
- calcium channel
- phosphatidylinositol-4,5-bisphosphate binding
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- coronary artery disease
- metabolic syndrome X
- mental retardation
- insulin-dependent diabetes mellitus
- pancreatic epithelial cancer
- restless legs syndrome
- mulibrey nanism
- major depression
- rubella
role in cell
- expression in
- elevation in
- calcium response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRPM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- protein tetramerization
- calcium ion transmembrane transport
- metal ion transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- cation channel activity