CHGB Gene Summary [Human]
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | CHGB |
| Official Name | chromogranin B [Source:HGNC Symbol;Acc:HGNC:1930] |
| Ensembl ID | ENSG00000089199 |
| Bio databases IDs | |
| Aliases | chromogranin B, secretogranin B |
| Synonyms | cgB, Chromogranin b, SCG1, sgI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHGB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone
- Granin (chromogranin or secretogranin)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- sporadic amyotrophic lateral sclerosis
- colorectal cancer
- epileptic seizure
- Huntington disease
- chronic fatigue syndrome
- familial amyotrophic lateral sclerosis
role in cell
- cell death
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- granules
- endoplasmic reticulum lumen
- zymogen granules
- neurites
- condensing vacuoles
- dense-core vesicles
- secretory granules
- Golgi cisternae
- membrane processes
- perikaryon
- immature secretory granules
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHGB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- secretory granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity