PRAG1 Gene Summary [Human]
This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | PRAG1 |
| Official Name | PEAK1 related, kinase-activating pseudokinase 1 [Source:HGNC Symbol;Acc:HGNC:25438] |
| Ensembl ID | ENSG00000275342 |
| Bio databases IDs | |
| Aliases | PEAK1 related, kinase-activating pseudokinase 1, Pragmin, RND2 effector protein, sugen kinase 223, PEAK family member 2 |
| Synonyms | 9830148H23, D8Ertd82e, mFLJ00269, NACK, PEAK1 related kinase activating pseudokinase 1, PEAK1 related, kinase-activating pseudokinase 1, PEAK2, PRAGMIN, RGD1311793, SGK223 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRAG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein kinase
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- metabolic syndrome X
- tumorigenesis
role in cell
- growth
- phosphorylation in
- expression in
- development
- formation
- contraction
- formation in
- tyrosine phosphorylation in
- elongation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- focal adhesions
- cytosol
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRAG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of Rho protein signal transduction
- negative regulation of neuron projection development
- regulation of Notch signaling pathway
- regulation of cell motility
- protein phosphorylation
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein kinase activity