POLR2E Gene Summary [Human]
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | POLR2E |
| Official Name | RNA polymerase II, I and III subunit E [Source:HGNC Symbol;Acc:HGNC:9192] |
| Ensembl ID | ENSG00000099817 |
| Bio databases IDs | |
| Aliases | RNA polymerase II, I and III subunit E, DNA directed RNA polymerase II 23 kda polypeptide |
| Synonyms | 2410021N14Rik, hRPB25, hsRPB5, LOC687055, polymerase (RNA) II (DNA directed) polypeptide E, RNA polymerase ii 23 kd subunit, RNA polymerase II, I and III subunit E, RPABC1, RPB5, XAP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase Rpb5, C-terminal domain
- DNA-directed RNA polymerase
- PLN03111
- RNA polymerase Rpb5, N-terminal domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLR2E gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription elongation from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- protein stabilization
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- RNA polymerase II activity
- protein binding
- RNA polymerase I activity
- DNA-directed RNA polymerase activity