WNK4 Gene Summary [Human]
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | WNK4 |
| Official Name | WNK lysine deficient protein kinase 4 [Source:HGNC Symbol;Acc:HGNC:14544] |
| Ensembl ID | ENSG00000126562 |
| Bio databases IDs | |
| Aliases | WNK lysine deficient protein kinase 4 |
| Synonyms | 2010002J11Rik, Ac2-059, PHA2B, PRKWNK4, WNK lysine deficient protein kinase 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- coiled-coil domain
- protein binding
- Protein kinase domain
- proline rich domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- Oxidative-stress-responsive kinase 1 C-terminal domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pseudohypoaldosteronism type IIB
- renal clear cell adenocarcinoma
- renal clear cell cancer
- pseudohypoaldosteronism type II
- polyuria
- androgenic alopecia
- hypokalemia
- alkalosis
role in cell
- growth
- activation in
- activation
- inhibition in
- response by
- ubiquitination in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- cellular membrane
- intercellular junctions
- cytosol
- lateral plasma membrane
- tight junctions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase C signaling cascade
- calcium ion homeostasis
- protein localization
- renal sodium ion transport
- response to dietary excess
- protein phosphorylation
- chloride transport
- macrophage activation
- inflammatory response
- aldosterone secretion
- intracellular signal transduction
- cellular chloride ion homeostasis
- potassium ion transmembrane transport
- signal transduction
- negative regulation of pancreatic juice secretion
- regulation of blood pressure
- renal sodium ion absorption
- ERK1 and ERK2 cascade
- distal tubule morphogenesis
- gene expression
- sodium ion transmembrane transport
- cellular response to xenobiotic stimulus
- ion homeostasis
- negative regulation of sodium ion transport
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoplasm
- membrane
- cell body
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- chloride ion binding
- protein binding
- protein kinase activity
- ion channel inhibitor activity
- protein serine/threonine kinase activity