FUT7 Gene Summary [Human]
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FUT7 |
| Official Name | fucosyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:4018] |
| Ensembl ID | ENSG00000180549 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 7, alpha (1,3) fucosyltransferase |
| Synonyms | AI853193, FTVII, fucosyltransferase 7, Fuc-TVII |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha(1,3)-fucosyltransferase
- hexosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
- protein binding
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Pathways
Biological processes and signaling networks where the FUT7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- diabetic nephropathy
- atopic dermatitis
- delayed hypersensitive reaction
- leukocyte adhesion deficiency
- infection
- hypoplasia
- ulcerative colitis
- leukocytosis
- infection by Anaplasma phagocytophilum
role in cell
- expression in
- cellular infiltration by
- migration
- differentiation
- adhesion
- recruitment
- development
- quantity
- number
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell adhesion molecule production
- regulation of cell-cell adhesion
- fucosylation
- positive regulation of cell-cell adhesion
- protein glycosylation
- oligosaccharide biosynthetic process
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- L-fucose catabolic process
- ceramide metabolic process
- positive regulation of cell adhesion
- regulation of insulin receptor signaling pathway
- embryo implantation
- leukocyte migration involved in immune response
- lymphocyte migration into lymph node
- inflammatory response
- leukocyte migration involved in inflammatory response
- T cell migration
- regulation of type IV hypersensitivity
- regulation of neutrophil extravasation
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- fucosyltransferase activity
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- protein binding
- alpha-(1->3)-fucosyltransferase activity