RRM2 Gene Summary [Human]
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | RRM2 |
| Official Name | ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol;Acc:HGNC:10452] |
| Ensembl ID | ENSG00000171848 |
| Bio databases IDs | |
| Aliases | ribonucleotide reductase regulatory subunit M2 |
| Synonyms | C2orf48, FLJ25102, R2, Ribonucleoside-diphosphate reductase M2 subunit, ribonucleotide reductase M2, Ribonucleotide reductase non-heme subunit, ribonucleotide reductase regulatory subunit M2, RIBONUCLEOTIDE REDUCTASE SMALL subunit, RNR beta2, RNRII, Rnr-r2, RR2, RR2M |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferric iron binding
- ribonucleoside-diphosphate reductase
- protein homodimerization
- enzyme
- protein binding
- identical protein binding
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic breast cancer
- metastatic colorectal cancer
- metastatic non-small cell lung cancer
- non-small cell lung cancer
- non-squamous lung carcinoma
- recurrent nonsquamous non-small cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- metastatic lung adenocarcinoma
- lung adenocarcinoma
role in cell
- phosphorylation in
- expression in
- cell viability
- cellular infiltration by
- apoptosis
- degradation in
- proliferation
- conversion in
- colony formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate metabolic process
- positive regulation of G1/S transition of mitotic cell cycle
- 2'-deoxyribonucleotide biosynthetic process
- deoxyribonucleotide biosynthetic process
- blastocyst development
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- ribonucleoside-diphosphate reductase complex
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- ferric iron binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor