WASHC2A Gene Summary [Human]
Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Involved in protein localization to endosome. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WASHC2A |
| Official Name | WASH complex subunit 2A [Source:HGNC Symbol;Acc:HGNC:23416] |
| Ensembl ID | ENSG00000099290 |
| Bio databases IDs | |
| Aliases | WASH complex subunit 2A |
| Synonyms | bA56A21.1, bA98I6.1, FAM21A, FAM21B, FLJ10824, WASH complex subunit 2A |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WASHC2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WASH complex subunit CAP-Z interacting, central region
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoli
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WASHC2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in endosome
- protein transport
- endosomal transport
- retrograde transport, endosome to Golgi
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- cytosol
- WASH complex
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding