PALM Gene Summary [Human]
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PALM |
| Official Name | paralemmin [Source:HGNC Symbol;Acc:HGNC:8594] |
| Ensembl ID | ENSG00000099864 |
| Bio databases IDs | |
| Aliases | paralemmin, paralemmin-1 |
| Synonyms | KIAA0270, PALM1, PARALEMMIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PALM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoylation site
- G-protein-coupled receptor binding
- protein binding
- MIU-linker domain found in unconventional myosin-VI
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
regulates
- ADCY
role in cell
- formation
- maturation
- quantity
- development
- organization
- branching
- expansion
- response by
- assembly
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apicolateral membrane
- glutaminergic synapse
- Cytoplasm
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- granules
- cytoplasmic face of plasma membrane
- basolateral membrane
- nucleoplasm
- dendritic spines
- growth cone
- neurites
- dendrite initial segments
- cytoplasmic vesicles
- membrane blebs
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PALM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- regulation of cell shape
- negative regulation of adenylate cyclase activity
- cytoskeleton organization
- synapse maturation
- positive regulation of filopodium assembly
- cellular response to electrical stimulus
- negative regulation of dopamine receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- postsynaptic density
- apicolateral plasma membrane
- dendritic spine
- cytoplasmic vesicle
- basolateral plasma membrane
- plasma membrane
- axon
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- D3 dopamine receptor binding