Palm Gene Summary [Mouse]
Enables D3 dopamine receptor binding activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of dendritic spine development; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of cell shape. Located in several cellular components, including filopodium; neuron spine; and postsynaptic density. Is expressed in several structures, including eye; liver; nasal epithelium; nervous system; and renal cortex. Orthologous to human PALM (paralemmin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Palm |
| Official Name | paralemmin [Source:MGI Symbol;Acc:MGI:1261814] |
| Ensembl ID | ENSMUSG00000035863 |
| Bio databases IDs | |
| Aliases | paralemmin |
| Synonyms | KIAA0270, PALM1, PARALEMMIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Palm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoylation site
- G-protein-coupled receptor binding
- protein binding
- MIU-linker domain found in unconventional myosin-VI
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
regulates
- ADCY
role in cell
- formation
- maturation
- quantity
- development
- organization
- branching
- expansion
- response by
- assembly
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apicolateral membrane
- glutaminergic synapse
- Cytoplasm
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- granules
- cytoplasmic face of plasma membrane
- basolateral membrane
- nucleoplasm
- dendritic spines
- growth cone
- neurites
- dendrite initial segments
- cytoplasmic vesicles
- membrane blebs
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Palm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- regulation of cell shape
- negative regulation of adenylate cyclase activity
- cytoskeleton organization
- synapse maturation
- positive regulation of filopodium assembly
- cellular response to electrical stimulus
- negative regulation of dopamine receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- postsynaptic density
- apicolateral plasma membrane
- dendritic spine
- cytoplasmic vesicle
- basolateral plasma membrane
- plasma membrane
- axon
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- D3 dopamine receptor binding