GNLY Gene Summary [Human]
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | GNLY |
| Official Name | granulysin [Source:HGNC Symbol;Acc:HGNC:4414] |
| Ensembl ID | ENSG00000115523 |
| Bio databases IDs | |
| Aliases | granulysin, T-lymphocyte activation gene 519 |
| Synonyms | D2S69E, Granulysin, LAG-2, NKG5, TLA519 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNLY often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Saposin-like type B, region 2
- protein binding
- Saposin (B) Domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute myeloid leukemia
- early-onset preeclampsia
- polyarticular juvenile rheumatoid arthritis
- preeclampsia
- septic shock
- early missed abortion
- chronic periodontal disease
- sepsis
role in cell
- differentiation
- growth
- cell viability
- quantity
- activation
- apoptosis
- disruption
- chemotaxis
- cell death
- viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- intracellular space
- organelle lumens
- lysosome
- granules
- cytotoxic granule
- early endosomes
- membrane rafts
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNLY gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- killing of cells of other organism
- defense response to fungus
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytolytic granule
- phagocytic vesicle lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding