JOSD1 Gene Summary [Human]
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | JOSD1 |
| Official Name | Josephin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28953] |
| Ensembl ID | ENSG00000100221 |
| Bio databases IDs | |
| Aliases | Josephin domain containing 1 |
| Synonyms | 1300006C06Rik, dJ508I15.2, Jos1, Josephin domain containing 1, mKIAA0063, RGD1305388 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JOSD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- protein binding
- Josephin
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
regulates
- p38 MAPK
- TF
- double-stranded DNA
- Lys48-linked polyubiquitin
- CtxB
- K63-linked polyubiquitin
- dextran
role in cell
- phosphorylation in
- breakage in
- dynamics in
- endocytosis by
- organization
- Clathrin mediated endocytosis by
- uptake by
- caveolin-mediated endocytosis by
- macropinocytosis by
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JOSD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding